In vitro–in vivo evaluation of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel implants containing cisplatin
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چکیده
منابع مشابه
Manufacture of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel tubes for use as nerve guidance channels.
Hydrogel tubes of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (p(HEMA-co-MMA)) made by liquid-liquid centrifugal casting are being investigated as potential nerve guidance channels in the central nervous system. An important criterion for the nerve guidance channel is that its mechanical properties are similar to those of the spinal cord, where it will be implanted. The formulated ...
متن کاملLong-term in vivo biomechanical properties and biocompatibility of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) nerve conduits.
Artificial grafts are promising alternatives to nerve grafts for peripheral nerve repair because they obviate the complications and disadvantages associated with autografting such as donor site morbidity and limited tissue availability. We have synthesized poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (PHEMA-MMA) porous tubes and studied their efficacy in vivo. Specifically, we studi...
متن کاملCisplatin delivery from poly(acrylic acid-co-methyl methacrylate) microparticles.
To develop a platform for tumor chemotherapy, poly(acrylic acid-co-methyl methacrylate) microparticles have been synthesized. Carboxylate containing monomers were included to complex therapeutic agents, specifically cisplatin. Microparticles were prepared by free radical emulsion polymerization in aqueous media. Particle diameter, zeta-potential, in vitro cytotoxicity, and in vivo acute toxicit...
متن کاملFeedback-regulated paclitaxel delivery based on poly(N,N-dimethylaminoethyl methacrylate-co-2-hydroxyethyl methacrylate) nanoparticles.
pH-Sensitive poly(N,N-dimethylaminoethyl methacrylate (DMAEMA)/2-hydroxyethyl methacrylate (HEMA)) nanoparticles were prepared for the triggered release of paclitaxel within a tumor microenvironment. Tumors exhibit a lower extracellular pH than normal tissues. We show that paclitaxel release from DMAEMA/HEMA particles can be actively triggered by small, physiological changes in pH (within 0.2-0...
متن کاملSolubility and diffusivity of solvents and nonsolvents in poly(methyl methacrylate co butyl methacrylate)
In this study, thermodynamic properties, namely retention volume, infinitely dilute weight fraction activity coefficient, Flory–Huggins interaction parameter, solubility parameter of the polymer, partition coefficient and diffusion coefficients of the various solvents in poly(methyl methacrylate co butyl methacrylate) (PMMA co BMA) at infinite dilution of the solvent have been determined by inv...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2011
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2011.09.001